Our Technologies

Molecular design to enhance agent efficacy

We also conduct computational chemistry and chemoinformatics research to rapidly discover new candidate compounds for agrochemicals.
We use molecular simulation and machine learning to analyze the relationship between the structure of compounds and their biological activities, and between the structure of compounds and their physicochemical properties.
These computational analyses assist in guiding rational molecular design.

Evaluation of agrochemical efficacy in our own fields

"Evaluation of agrochemical efficacy in our own fields"
In order to conduct more practical biological research on fungicides, insecticides, acaricides, herbicides and biopesticides, it is necessary to carry out tests under conditions similar to practical situations. Considering various environmental conditions and crop species, we conduct tests in several fields in Japan and abroad.

Formulations tailored to the properties of agrochemicals

Agrochemicals formulations come in many dosage forms, from solid to liquid, such as granules and liquid agents. In addition, agrochemicals formulations contain surfactants and bulking agents for effectiveness. We start our research with a few dozen milligrams of a new active ingredients. We are researching to create environment- and people-friendly formulations by maximizing the ability of the active ingredients under the application conditions.

Bioactivity evaluation

We evaluate the bioactivity of newly synthesized compounds against pathogens, pests, and weeds through laboratory and pot tests. We use efficient screening methods for a large number of compounds to determine their potential as fungicides, insecticides, miticides, and herbicides. We also use biochemical, physiological, and molecular biological methods to create agrochemicals with new actions.

Pharmacology, Toxicity, Pharmacokinetic, and Accumulation evaluation

A wide range of tests are required in pharmacological and toxicological research to estimate and evaluate the effects of agrichemicals on the human body. We are involved in various phases of development research to develop safe agrichemicals. Additionally, in order to investigate the effects of agrichemicals on exposure, we investigate and analyze the behavior and metabolites/degradation products in animals, plants, and the environment in pharmacokinetic and accumulation evaluation. . These results are used to evaluate the safety of agrichemicals.

Design and synthesis of organic compounds

In the search for new pesticides, we start with seed and lead compounds and optimize them using organic synthetic chemistry. In the process, we must resolve various issues such as biological activity, pharmacodynamics, animal and environmental toxicity, and novelty.
In order to explore the factors involved in these issues and design appropriate compounds that can be solved, we conduct daily synthetic research while holding discussions with researchers in biological and analytical systems.

Analysis and characterization of organic compounds

We support various businesses for the research and development, marketing and dissemination of materials and agrochemicals. We develop analytical evaluation methods and acquire new analytical techniques related to various evaluation technologies.

Flow reaction, Low temperature reaction and High pressure reaction

We have developed synthesis processes for special conditions such as flow, low temperature, and high pressure reactions and are applying them to actual manufacturing plants.

Related product information can be found on the following business pages.

Specialty Chemicals

Typical reaction examples

Related product information can be found on NISSO-PB pages.

Polymer synthesis and Anion polymerization

In addition to developing high-performance materials utilizing our company's proprietary products of polybutadiene and SBS, we are also developing new polymers with excellent material properties such as high heat resistance and low dielectric properties by applying our company polymerization technology as next-generation high-speed communication materials.

We mainly synthesize polymers utilizing living anionic polymerization technology.

Related product information can be found on the following business pages.

Specialty Chemicals

Typical reaction examples

*1 Related product information can be found on NISSO-PB pages.

*2 Related product information can be found on Liquid_1,2-SBS.pdf pages.

Production and Handling of poisonous and deleterious substances

We safely produce and handle a large number of poisonous substances.

• Registration for poison substances Manufacture　5 compounds, including POCl₃ and NaCN
• Registration for deleterious substances Manufacture　43 compounds, including Cl₂ and NaOH
• We also handle many other compounds.

Production and handling of water-prohibited compounds

We safely produce and handle a large number of water-prohibited compounds.

Related product information can be found on the following business pages.

Specialty Chemicals

Typical production and handling examples

*1 Related product information can be found on Organic Titanate pages.

*2 Related product information can be found on NISSO-PB pages.

Examples of hazardous gases

Many hazardous gases, such as chlorine and its derivatives, hydrogen cyanide, and ethylene oxide, are produced safely and applied to unique reactions.

Related product information can be found on the following business pages.

Production of chlorine and reaction examples

Examples of reactions using hydrogen chloride

Examples of reactions using phosgene

Examples of reactions using hydrogen cyanide

*1 Related product information can be found on Chlor-Alkali pages.

*2 Related product information can be found on Pharmaceuticals pages.

Examples of reactions using ethylene oxide

Examples of reactions using propylene oxide

*3 Related product information can be found on Pharmaceuticals pages.

Pharmaceutical grade manufacturing technology and quality control

We produce a large number of active pharmaceutical ingredients and pharmaceutical intermediates with the pharmaceutical manufacturing technology and quality control system we have developed over many years.

Related product information can be found on the following business pages.

Pharmaceuticals

Typical reaction examples

Bactericides and antimicrobial agents, Biocide product development

Biocide-related products are chemicals that control pests (Viruses, bacteria, molds, algae, termites, etc.) in the general industrial sector, and are applied to various fields such as paints, plastics, rubber, paper pulp, wood, building materials, and textiles. Utilizing our own agrochemical development technology, we combine active ingredient search, formulation technology, bioactivity evaluation, and analytical evaluation technology to develop products that respond flexibly to user needs.