NISSO HPC

Pharma

Application

Lower molecular weight/viscosity grades of NISSO HPC can be effectively used for fast dissolving ODT formulations. HPC SSL and HPC SSL-SFP are recommended

Lower molecular weight/viscosity grades of NISSO HPC can be effectively used for ODF formulations. HPC SSL is recommended.

Higher molecular weight/viscosity grades of NISSO HPC can be used for controlled release hydrophilic matrix tablets. Typical addition rate between 20-30% for effective delayed release of active ingredients are possible. HPC H and VH are recommended.

NISSO HPC Grades
NISSO HPC SSL SL L M H VH
Viscosity (mPa·s)
20℃/2% aq. solution
2.0-2.9 3.0-5.9 6.0-10.0 150-400 1000-4000 4001-6000
Molecular weight / GPC-RI method 40,000 100,000 140,000 700,000 1,000,000 2,500,000
AVAILABILITY Regular Powder
(40 mesh pass)
D50: 150-190 μm
Fine Powder
(100 mesh pass)
D50: 80-110 μm
Super Fine Powder
(330 mesh pass)
D50: 20 μm
APPLICATION Controlled Release Matrix Tablets

 Particle size of the Regular Powder: 85μm

A = Dry / Powder Use

B = Wet / Solution Use

NISSO HPC is suitable for both aqueous and organic coating systems. It provides a robust yet flexible film coating with low tackiness, high moisture barrier properties as well as sharper imprint definition. HPC L, SL and SSL are recommended.

NISSO HPC Grades
NISSO HPC SSL SL L M H VH
Viscosity (mPa·s)
20℃/2% aq. solution
2.0-2.9 3.0-5.9 6.0-10.0 150-400 1000-4000 4001-6000
Molecular weight / GPC-RI method 40,000 100,000 140,000 700,000 1,000,000 2,500,000
AVAILABILITY Regular Powder
(40 mesh pass)
D50: 150-190 μm
Fine Powder
(100 mesh pass)
D50: 80-110 μm
Super Fine Powder
(330 mesh pass)
D50: 20 μm
APPLICATION Film Coating
Plasticizer for Film Coating

 Particle size of the Regular Powder: 85μm

A = Dry / Powder Use

B = Wet / Solution Use

Through solubility enhancement methods such as hot melt extrusion, spray drying or nano-suspension, NISSO HPC can act as the stabilizing polymer for the amorphous solid dispersion matrix.

NISSO HPC SSL SL L M H VH
Viscosity (mPa·s)
20℃/2% aq. solution
2.0-2.9 3.0-5.9 6.0-10.0 150-400 1000-4000 4001-6000
Molecular weight / GPC-RI method 40,000 100,000 140,000 700,000 1,000,000 2,500,000
AVAILABILITY Regular Powder
(40 mesh pass)
D50: 150-190 μm
Fine Powder
(100 mesh pass)
D50: 80-110 μm
Super Fine Powder
(330 mesh pass)
D50: 20 μm
APPLICATION hot melt extrusion
spray drying
nano-suspension

 Particle size of the Regular Powder: 85μm

A = Dry / Powder Use

B = Wet / Solution Use

NISSO HPC is suitable for sterile filtration application because of its high purity and lack of additives such as silica. Filtration efficiency depends on the concentration of HPC, its viscosity as well as the filter used. HPC SSL, SL and L are recommended.

NISSO HPC SSL SL L M H VH
Viscosity (mPa·s)
20℃/2% aq. solution
2.0-2.9 3.0-5.9 6.0-10.0 150-400 1000-4000 4001-6000
Molecular weight / GPC-RI method 40,000 100,000 140,000 700,000 1,000,000 2,500,000
AVAILABILITY Regular Powder
(40 mesh pass)
D50: 150-190 μm
Fine Powder
(100 mesh pass)
D50: 80-110 μm
Super Fine Powder
(330 mesh pass)
D50: 20 μm
APPLICATION Sterile Filtration

 Particle size of the Regular Powder: 85μm

A = Dry / Powder Use

B = Wet / Solution Use